Understanding how Notch signaling affects treatment failure in rheumatoid arthritis
A Notch-mediated fibrogenic program drives treatment failure in rheumatoid arthritis
This study is looking into how certain cells in your joints might be causing treatments for rheumatoid arthritis to not work as well as they should, and it hopes to find new ways to help improve your treatment by focusing on these cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11022050 on NIH RePORTER |
What this research studies
This research investigates the cellular mechanisms that lead to treatment failure in rheumatoid arthritis (RA), focusing on the role of Notch signaling in joint fibroblast activation and fibrosis. By using advanced techniques like single-cell and spatial transcriptomic profiling, the study aims to uncover how Notch signaling regulates fibrogenesis and its impact on joint inflammation and treatment response. The ultimate goal is to explore targeting fibroblasts as a new adjuvant therapy for RA, potentially improving treatment outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with rheumatoid arthritis who are experiencing treatment resistance.
Not a fit: Patients with rheumatoid arthritis who are currently responding well to existing treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that enhance the effectiveness of existing therapies for rheumatoid arthritis.
How similar studies have performed: Previous research has shown promising results in targeting cellular mechanisms in rheumatoid arthritis, suggesting that this approach could yield significant insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Wei, Kevin S — Brigham and Women's Hospital
- Study coordinator: Wei, Kevin S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.