Understanding how Notch signaling affects lymphatic vessels in adults
Notch Signaling in the Adult Lymphatic Vasculature
This study is looking at how a specific signaling system in our bodies, called Notch, helps keep our lymphatic vessels healthy and functioning well, which is important for everyone, especially those dealing with conditions like cancer or metabolic disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10996189 on NIH RePORTER |
What this research studies
This research investigates the role of Notch signaling in the growth and function of lymphatic vessels in adults, particularly focusing on how it influences lymphatic endothelial cells. The study aims to understand the distinct roles of Notch receptors and ligands in maintaining lymphatic health and how their dysfunction can lead to various diseases, including cancer and metabolic disorders. By using both animal models and in vitro studies, the researchers will explore how Notch signaling affects cell proliferation and the overall behavior of lymphatic cells. This research could provide insights into potential therapeutic targets for conditions related to lymphatic dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research include adult females experiencing lymphatic-related health issues or conditions linked to lymphatic dysfunction.
Not a fit: Patients with conditions unrelated to lymphatic function or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases associated with lymphatic dysfunction, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in targeting Notch signaling pathways for therapeutic purposes, indicating potential for success in this area.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Shawber, Carrie J. — Columbia University Health Sciences
- Study coordinator: Shawber, Carrie J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.