Understanding how Notch signaling affects intestinal stem cells
Official title: Defining the Notch niche for Intestinal Stem cells
Funded at University of Michigan at Ann Arbor · NIH-11067024 · Data updated 2026-11-12
This study is looking at how certain signals in the body help keep the stem cells in our gut healthy and working well, which could lead to new ways to treat gut problems and improve overall digestive health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $75,520 |
| NIH project number | 1F32DK142253-01 |
| Project ID | NIH-11067024 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with gastrointestinal disorders or those interested in the biological mechanisms of gut health.
✕Less likely to help
Patients with non-gastrointestinal conditions or those who are not affected by stem cell-related issues may not benefit from this research.
What this research studies
This research investigates the role of Notch signaling in the maintenance and regulation of intestinal stem cells, which are crucial for gut health. The study aims to uncover how these signals operate in both immature and adult stem cells, particularly focusing on their interactions with neighboring Paneth cells. By exploring these mechanisms, the research seeks to provide insights into how stem cells can self-renew and repair the intestinal lining after injury. Patients may benefit from a better understanding of gut health and potential new therapies for gastrointestinal disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for gastrointestinal diseases by enhancing our understanding of stem cell behavior in the intestine.
How similar studies have gone: Previous research has shown promising results in understanding stem cell signaling pathways, indicating that this approach has potential for success.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Quintero, Michaela Katherine — University of Michigan at Ann Arbor
- Study coordinator: Quintero, Michaela Katherine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.