Understanding how Notch receptors interact with their partners
Illuminating Notch receptor-ligand selectivity through structure-guided protein engineering
This study is exploring how to better control a key signaling system in our cells, which could help create new treatments for patients by either boosting or slowing down cell activity as needed.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11012095 on NIH RePORTER |
What this research studies
This research investigates the Notch signaling pathway, which plays a crucial role in the development of stem cells and immune cells. By using advanced protein engineering techniques, the team aims to create tools that can precisely control Notch signaling in specific tissues. This could lead to new therapies that enhance or inhibit cell signaling based on the needs of the patient. The research focuses on understanding the structure of Notch receptors and their interactions with other proteins to develop customizable signaling outputs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to stem cell development or immune system disorders.
Not a fit: Patients with conditions unrelated to stem cell or immune cell development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve stem cell therapies and immune responses.
How similar studies have performed: Other research has shown promising results in manipulating signaling pathways for therapeutic purposes, indicating potential success for this approach.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Luca, Vincent Christopher — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Luca, Vincent Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.