Understanding how Notch proteins affect blood vessel growth
Investigating tyrosine phosphorylation of Notch proteins
This study is looking at how certain proteins help control the growth of blood vessels, which is important for both healthy and sick people, and it also offers a chance for students to learn more about this exciting area of science.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boise State University NIH-funded |
| Lab location | 1 site (Boise, United States) |
| Project ID | NIH-10578301 on NIH RePORTER |
What this research studies
This research investigates the role of Notch proteins and their phosphorylation in regulating blood vessel formation, a process known as angiogenesis. By examining how these proteins interact with the extracellular matrix and integrins, the study aims to uncover new signaling mechanisms that influence cellular behavior in both healthy and diseased states. The research will involve laboratory techniques to analyze these interactions and their effects on vascular function, while also providing educational opportunities for students in the field of science.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that affect blood vessel health, such as diabetes or vascular disorders.
Not a fit: Patients with stable vascular health or those not experiencing any related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treatments for diseases related to blood vessel dysfunction, such as diabetes and fibrosis.
How similar studies have performed: Other research has shown promising results in understanding the role of Notch signaling in vascular biology, suggesting that this approach could yield valuable insights.
Where this research is happening
Boise, United States
- Boise State University — Boise, United States (Active)
Researchers
- Principal investigator: Albig, Allan R — Boise State University
- Study coordinator: Albig, Allan R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.