Understanding how norovirus interacts with the gut barrier in causing gastroenteritis
The Role of Norovirus Interactions with the Epithelial Barrier in Acute Gastroenteritis
This study is looking at how norovirus, which causes bad diarrhea, affects the intestines and immune cells, especially in kids, to help find better treatments for the virus.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11085961 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which norovirus, a leading cause of severe diarrhea, interacts with the epithelial barrier in the intestines. Using a novel animal model, the study aims to understand how the virus infects immune cells without affecting the intestinal lining, which could provide insights into the disease process. The findings may help identify potential antiviral treatments and improve our understanding of norovirus infections, particularly in children. By studying these interactions, researchers hope to pave the way for developing effective therapies against norovirus.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals, particularly children, who experience acute gastroenteritis symptoms caused by norovirus.
Not a fit: Patients with gastroenteritis caused by other pathogens or those who do not exhibit symptoms related to norovirus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted antiviral therapies for norovirus infections, significantly improving treatment options for affected patients.
How similar studies have performed: Previous research using animal models has successfully advanced our understanding of viral infections, suggesting that this approach may yield valuable insights into norovirus as well.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Peiper, Amy Marie — University of Florida
- Study coordinator: Peiper, Amy Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.