Understanding how nonmuscle myosins work in cells
Structure and function of nonmuscle myosins
This study is looking at how a special protein called nonmuscle myosin-2 helps our cells move and grow, and it aims to understand how this protein works so that we can create better treatments for diseases like cancer and heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10878777 on NIH RePORTER |
What this research studies
This research investigates the structure and function of nonmuscle myosin-2 (NM2) motors, which are crucial for various cellular processes such as migration, division, and adhesion. By using advanced techniques like cryo-electron microscopy and X-ray crystallography, the researchers aim to uncover how NM2 motors switch between active and inactive states and how this regulation affects cellular functions. The findings could lead to the development of targeted therapies for diseases linked to NM2 dysfunction, including certain cancers and heart diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to NM2 dysfunction, such as certain cancers, blood disorders, or cardiac diseases.
Not a fit: Patients with conditions unrelated to NM2 or those who do not have any cellular dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for diseases caused by NM2 dysfunction, improving treatment options for patients.
How similar studies have performed: Other research has shown promising results in understanding the role of myosins in cellular processes, indicating that this approach has potential for success.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Chinthalapudi, Krishna — Ohio State University
- Study coordinator: Chinthalapudi, Krishna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.