Understanding how noncoding RNAs influence gene regulation and disease
Mechanisms of heterochromatin targeting and epigenetic genome regulation
This study is looking at how certain tiny molecules in our cells help control gene activity and stability, which could lead to better treatments for diseases caused by gene mismanagement.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11000799 on NIH RePORTER |
What this research studies
This research investigates the role of noncoding RNAs (ncRNAs) in the formation and function of heterochromatin, which is crucial for proper gene regulation and stability in multi-cellular organisms. By exploring how these ncRNAs interact with chromatin and RNA-binding proteins, the research aims to uncover the molecular mechanisms behind gene expression regulation. Patients may benefit from insights gained into how mis-regulation of heterochromatin contributes to various diseases, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to epigenetic changes and gene expression disorders.
Not a fit: Patients with conditions unrelated to epigenetic regulation or those not affected by gene expression mis-regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for diseases caused by gene expression mis-regulation.
How similar studies have performed: Other research has shown promising results in understanding the role of ncRNAs in gene regulation, suggesting that this approach could yield significant insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Johnson, Aaron M. — University of Colorado Denver
- Study coordinator: Johnson, Aaron M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.