Understanding how noncoding RNAs are destroyed in the body
Destruction of noncoding RNAs - R35 Diversity Supplement
This study is looking into how certain important RNA molecules, which help control gene activity and are linked to various diseases, break down in the body, with the hope of finding new ways to understand and treat those conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11100770 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the degradation of noncoding RNAs, which play crucial roles in regulating gene expression and are important for development and disease. The study focuses on specific types of noncoding RNAs, such as microRNAs and circular RNAs, that resist traditional degradation pathways. By identifying how these RNAs are destroyed, the research aims to uncover new insights into gene regulation and potential therapeutic targets. Patients may benefit from a better understanding of diseases linked to these RNA molecules.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include children aged 0-11 years who may have conditions related to gene expression dysregulation.
Not a fit: Patients with conditions unrelated to noncoding RNA mechanisms or those outside the age range of 0-11 years may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases associated with noncoding RNAs, particularly in children.
How similar studies have performed: While the specific focus on the degradation of noncoding RNAs is relatively novel, there have been successful studies exploring RNA regulation that support the potential for impactful findings.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Kleaveland, Benjamin Monteverde — Weill Medical Coll of Cornell Univ
- Study coordinator: Kleaveland, Benjamin Monteverde
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.