Understanding how noncoding RNAs are destroyed in the body
Destruction of noncoding RNAs
This study is looking at how certain tiny molecules in our cells, called noncoding RNAs, are broken down and how this affects gene regulation, which is important for understanding diseases like cancer, especially in children.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10888378 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the destruction of noncoding RNAs, which play crucial roles in regulating gene expression and are important in various diseases, including cancers. The study focuses on specific types of noncoding RNAs, such as microRNAs, and aims to identify how they are degraded in the body, particularly through a process called target-directed miRNA degradation (TDMD). By exploring the proteins involved in this degradation process, the research seeks to fill gaps in our understanding of gene regulation and its implications for health and disease, especially in children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and young individuals aged 0-21 who may be affected by conditions related to noncoding RNA dysfunction.
Not a fit: Patients outside the age range of 0-21 or those with conditions unrelated to noncoding RNA regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to noncoding RNA dysregulation, particularly in pediatric populations.
How similar studies have performed: While the specific mechanisms of noncoding RNA degradation are still being explored, related research has shown promise in understanding RNA regulation and its implications for treatment.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Kleaveland, Benjamin Monteverde — Weill Medical Coll of Cornell Univ
- Study coordinator: Kleaveland, Benjamin Monteverde
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.