Understanding how noncoding genetic variations contribute to multiple sclerosis
Deciphering the role of noncoding variation in the pathogenesis of multiple sclerosis
This study is looking at how certain genetic differences might affect the immune response in people with multiple sclerosis (MS), with the hope of finding new ways to understand and treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10853080 on NIH RePORTER |
What this research studies
This research investigates the role of noncoding genetic variations in the development of multiple sclerosis (MS), a chronic inflammatory disease affecting the brain and spinal cord. By examining how these variations influence T cell responses to myelin antigens, the study aims to identify specific genetic factors that contribute to the disease. The researchers utilize advanced genomic techniques to map these variations and their interactions with target genes, focusing on the behavior of pathogenic T helper cells in MS patients. This approach could lead to a better understanding of the underlying mechanisms of MS and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis, particularly those with a genetic predisposition to the disease.
Not a fit: Patients with other neurological conditions or those without a diagnosis of multiple sclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for patients with multiple sclerosis.
How similar studies have performed: Previous research has shown promise in understanding genetic contributions to autoimmune diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Ciofani, Maria — Duke University
- Study coordinator: Ciofani, Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.