Understanding how noncoding genetic variations affect mosaic diseases
Insights to Noncoding Disease Variants using Mosaic Diseases
This study is looking at how certain genetic changes that don't directly code for proteins might affect mosaic diseases, which are conditions where some of your cells have different genetic makeups, to help us understand these diseases better and find new ways to treat them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11074253 on NIH RePORTER |
What this research studies
This research investigates the role of noncoding genetic variants in mosaic diseases, which are conditions where some cells in the body have different genetic makeups. By analyzing these noncoding RNA variants, the research aims to uncover insights into how they contribute to the development and progression of these disorders. Patients may benefit from a better understanding of their conditions and potential new therapeutic approaches based on these findings. The research employs advanced genomic techniques to identify and characterize these variants in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with mosaic diseases or disorders linked to noncoding RNA variations.
Not a fit: Patients with conditions unrelated to mosaicism or noncoding RNA variations may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for patients with mosaic diseases.
How similar studies have performed: While the exploration of noncoding RNA in mosaic diseases is a relatively novel approach, there have been successful studies in related areas that suggest potential for impactful findings.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Sun, Bryan — University of California-Irvine
- Study coordinator: Sun, Bryan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.