Understanding how noncoding DNA affects neuroblastoma in children
Elucidating the role of the noncoding genome in neuroblastoma
This study is looking at how certain parts of DNA that don't make proteins might play a role in neuroblastoma, a type of childhood cancer, to help us understand how these changes can lead to the disease and find new ways to fight it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11045712 on NIH RePORTER |
What this research studies
This research investigates the role of noncoding regions of DNA in neuroblastoma, a serious childhood cancer. By analyzing genetic variations that do not code for proteins, the study aims to uncover how these changes can disrupt normal cellular functions and contribute to tumor development. The researchers will utilize advanced techniques such as whole genome sequencing and ATAC-seq to explore the epigenomic landscape of neuroblastoma cells and their precursors. This comprehensive approach seeks to identify specific noncoding variants that may influence the initiation and progression of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old diagnosed with neuroblastoma or those at risk due to genetic factors.
Not a fit: Patients with neuroblastoma who do not have identifiable noncoding genetic variants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into neuroblastoma, potentially improving diagnosis and treatment options for affected children.
How similar studies have performed: While the role of noncoding DNA in cancer is an emerging field, previous studies have shown promising results in understanding other cancers, suggesting potential for success in this area as well.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Diskin, Sharon — Children's Hosp of Philadelphia
- Study coordinator: Diskin, Sharon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.