Understanding how non-typhoidal Salmonella spreads in the bloodstream
Official title: Genetic Analyses of bacteremia non-typhoidal Salmonella
Funded at University of Louisville · NIH-10580145 · Data updated 2026-11-12
This study is looking at how a type of bacteria called non-typhoidal Salmonella can cause serious infections in the bloodstream, and it aims to find new ways to treat these infections by understanding how the bacteria avoid the immune system and spread in the body.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $469,500 |
| NIH project number | 1R15AI174177-01 |
| Project ID | NIH-10580145 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced or are at high risk for infections caused by non-typhoidal Salmonella.
✕Less likely to help
Patients with infections caused by other types of bacteria or those who do not have a history of bacteremia may not benefit from this research.
What this research studies
This research investigates the mechanisms by which non-typhoidal Salmonella bacteria cause severe bloodstream infections, known as bacteremia. The team will explore how certain bacterial factors, particularly the SpvC protein, help the bacteria evade the immune system and spread throughout the body. Using advanced laboratory techniques, they will model how these bacteria interact with immune cells and the blood vessel lining. The ultimate goal is to identify new treatment strategies that could reduce the severity and fatality of these infections.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly lower the risk of death from bacteremia caused by non-typhoidal Salmonella.
How similar studies have gone: Previous research has shown promise in understanding bacterial virulence factors, suggesting that this approach could yield valuable insights and potential breakthroughs.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Worley, Micah — University of Louisville
- Study coordinator: Worley, Micah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.