Understanding how non-small cell lung cancer cells change and adapt
Resolving epigenetic determinants of cellular plasticity programs in non-small cell lung cancer
This study is looking at how non-small cell lung cancer cells can change when treated, and it aims to find ways to stop these changes so that treatments can work better for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10990251 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind how non-small cell lung cancer (NSCLC) cells can change their characteristics in response to treatment, particularly focusing on a process called cellular plasticity. By using advanced techniques like CRISPR and single-cell RNA sequencing, the researchers aim to identify the molecular programs that control these changes. The study will utilize mouse models and organoids that mimic human tumors to explore how these adaptations occur and how they can be prevented, potentially leading to more effective treatments for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-small cell lung cancer, particularly those who may be facing challenges with treatment resistance.
Not a fit: Patients with other types of lung cancer or those who are not currently undergoing treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing drug resistance in lung cancer, improving treatment outcomes for patients.
How similar studies have performed: Other research has shown promising results in understanding cellular plasticity in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Patel, Ayushi — New York University School of Medicine
- Study coordinator: Patel, Ayushi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.