Understanding how non-small cell lung cancer cells change and adapt
Official title: Resolving epigenetic determinants of cellular plasticity programs in non-small cell lung cancer
Funded at New York University School of Medicine · NIH-10990251 · Data updated 2026-11-12
This study is looking at how non-small cell lung cancer cells can change when treated, and it aims to find ways to stop these changes so that treatments can work better for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $43,550 |
| NIH project number | 1F99CA294252-01 |
| Project ID | NIH-10990251 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with non-small cell lung cancer, particularly those who may be facing challenges with treatment resistance.
✕Less likely to help
Patients with other types of lung cancer or those who are not currently undergoing treatment may not benefit from this research.
What this research studies
This research investigates the mechanisms behind how non-small cell lung cancer (NSCLC) cells can change their characteristics in response to treatment, particularly focusing on a process called cellular plasticity. By using advanced techniques like CRISPR and single-cell RNA sequencing, the researchers aim to identify the molecular programs that control these changes. The study will utilize mouse models and organoids that mimic human tumors to explore how these adaptations occur and how they can be prevented, potentially leading to more effective treatments for patients.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing drug resistance in lung cancer, improving treatment outcomes for patients.
How similar studies have gone: Other research has shown promising results in understanding cellular plasticity in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Patel, Ayushi — New York University School of Medicine
- Study coordinator: Patel, Ayushi
Related research
Other NIH-funded projects on the same topics.
-
ABL kinase signaling and DNA collisions in small cell lung cancer
A drug target study in small cell lung cancer explores how blocking ABL kinase affects conflicts between transcription and DNA replication, which could influence tumor growth and survival.
-
XRN1 as a potential therapy target in lung cancer
A scientist-led program will study a cellular gene called XRN1 to see if turning it off can help treat non-small cell lung cancer.
-
Intermittent fasting with PD-1 inhibitors for non-small cell lung cancer
This grant tests whether a fasting-mimicking diet can boost the effectiveness of PD-1 inhibitors for people with non-small cell lung cancer.
-
Targeting STRAP to curb NSCLC spread with nanoparticle therapy
Aimed at non-small cell lung cancer, this grant tests how blocking a protein called STRAP with nanoparticles could slow cancer spread and make chemotherapy work better.
-
Modeling tumor differences to guide new treatments for resistant small cell lung cancer
A study aims to understand why some small cell lung cancer tumors resist treatment and use those insights to develop new targeted therapies.
-
TP53-mutant NSCLC: how epigenetic viral mimicry could boost immune therapy
A research grant exploring how p53 mutations in non-small cell lung cancer affect responses to a viral mimicry-based epigenetic therapy, with the goal of improving immune therapy outcomes for patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.