Understanding how non-muscle-invasive bladder cancer can progress to muscle-invasive cancer
Project 2
This study is looking at how non-muscle-invasive bladder cancer can change into a more serious form, muscle-invasive bladder cancer, to help doctors figure out which patients might be at higher risk and improve their treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10708903 on NIH RePORTER |
What this research studies
This research investigates the progression of non-muscle-invasive bladder cancer (NMIBC) to muscle-invasive bladder cancer (MIBC), which significantly impacts patient survival. The study aims to identify specific mechanisms that drive this progression and to develop risk stratification methods to predict which patients are likely to experience this change. By utilizing advanced techniques like single nuclei RNA sequencing, researchers will analyze cancer cell populations and their interactions with surrounding cells to uncover actionable insights. This approach could lead to better monitoring and treatment strategies for patients with NMIBC.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-muscle-invasive bladder cancer who are at risk of progression to muscle-invasive disease.
Not a fit: Patients with muscle-invasive bladder cancer or those without a diagnosis of bladder cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted therapies for patients with non-muscle-invasive bladder cancer.
How similar studies have performed: Previous research has shown promise in understanding cancer progression through similar molecular profiling techniques, indicating potential for success in this approach.
Where this research is happening
Houston, United States
- Methodist Hospital Research Institute — Houston, United States (Active)
Researchers
- Principal investigator: Theodorescu, Dan — Methodist Hospital Research Institute
- Study coordinator: Theodorescu, Dan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.