Understanding how non-genetic factors affect survival in children with Hirschsprung disease
Defining non-genetic mechanisms that prevent death in a Hirschsprung disease mouse model
This study is looking at how things like diet and gut bacteria can affect the health of kids with Hirschsprung disease, with the hope of finding ways to help them feel better and live healthier lives after surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10850960 on NIH RePORTER |
What this research studies
This research investigates the factors that influence the health outcomes of children with Hirschsprung disease, a serious condition affecting bowel function due to the absence of the enteric nervous system. The study uses a mouse model to explore how non-genetic elements, such as diet and gut bacteria, may impact the severity of symptoms and the risk of life-threatening complications. By examining these factors, the research aims to identify potential interventions that could improve the quality of life for affected children. The findings could lead to better management strategies for those who experience ongoing health issues after surgery.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with Hirschsprung disease, particularly those experiencing complications like enterocolitis.
Not a fit: Patients without Hirschsprung disease or those who have already undergone definitive treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better health outcomes for children with Hirschsprung disease.
How similar studies have performed: Previous research has shown promise in understanding the role of non-genetic factors in other gastrointestinal conditions, suggesting potential for success in this area as well.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Heuckeroth, Robert O — Children's Hosp of Philadelphia
- Study coordinator: Heuckeroth, Robert O
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.