Understanding how non-coding RNAs regulate gene expression
Regulation, evolution, and function of promoter-associated non-coding RNAs
This study is looking at how certain tiny molecules in our cells, called non-coding RNAs, help control the way our genes work, which is important for how our bodies respond to different changes and grow, and it’s for anyone interested in understanding more about how genes are regulated and how new genes might evolve.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project ID | NIH-10476538 on NIH RePORTER |
What this research studies
This research investigates the role of non-coding RNAs (ncRNAs) in regulating the transcription of protein-coding genes, which is crucial for how cells respond to various environmental and developmental signals. The project aims to identify the mechanisms that control the production and degradation of ncRNAs, explore their effects on gene transcription and RNA processing, and examine their potential role in the evolution of new genes. By developing new experimental and computational methods, the research seeks to comprehensively identify and classify these non-coding transcripts to better understand their functions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or diseases that may be influenced by gene expression and regulation.
Not a fit: Patients with conditions unrelated to gene expression or those not affected by non-coding RNA mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation, potentially impacting treatments for diseases linked to gene expression abnormalities.
How similar studies have performed: While the role of ncRNAs in gene regulation is an emerging field, previous studies have shown promising results in understanding their functions, indicating potential for success in this area.
Where this research is happening
Storrs-Mansfield, United States
- University of Connecticut Storrs — Storrs-Mansfield, United States (Active)
Researchers
- Principal investigator: Core, Leighton James — University of Connecticut Storrs
- Study coordinator: Core, Leighton James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.