Understanding how non-coding RNAs affect muscle health and disease
Official title: Mapping the non-coding RNA landscape in skeletal muscle health and disease
Funded at Cornell University · NIH-10829446 · Data updated 2026-11-12
This study is looking at how certain RNA molecules affect muscle health and disease, especially in people with Facioscapulohumeral muscular dystrophy (FSHD), to help us understand muscle weakness better and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | April 17, 2023 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $692,825 |
| NIH project number | 5R01AR081449-02 |
| Project ID | NIH-10829446 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Facioscapulohumeral muscular dystrophy (FSHD) or other related muscle disorders.
✕Less likely to help
Patients with muscle diseases not related to non-coding RNA dysregulation may not benefit from this research.
What this research studies
This research investigates the role of non-coding RNAs in the health and disease of skeletal muscle, particularly focusing on Facioscapulohumeral muscular dystrophy (FSHD), a condition that leads to muscle weakness. The project aims to map the complex interactions of these non-coding RNAs and their impact on muscle cell functions. By utilizing advanced profiling technologies, the researchers will explore how these RNA molecules regulate muscle cell identities and contribute to disease mechanisms. This comprehensive approach could lead to new insights into muscle disorders and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective therapies for muscle diseases like FSHD.
How similar studies have gone: While the role of non-coding RNAs in muscle health is an emerging field, previous studies have shown promising results in understanding their impact on various diseases, indicating potential for success in this area.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Cosgrove, Benjamin David — Cornell University
- Study coordinator: Cosgrove, Benjamin David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.