Understanding how non-coding RNAs affect gene regulation in malaria parasites
Deciphering the Role of Non-Coding RNAs in Gene Regulation
This study is looking at how certain RNA molecules in the malaria parasite might help control its genes and development, which could lead to new ways to treat malaria and make it easier to fight.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-11065394 on NIH RePORTER |
What this research studies
This research investigates the role of long non-coding RNAs (lncRNAs) in the gene regulation and development of the malaria parasite Plasmodium falciparum. By utilizing advanced techniques like ChAR-seq and RADICL-seq, the study aims to uncover how these RNA molecules influence chromatin organization and epigenetic changes that affect the parasite's virulence and lifecycle. The findings could lead to novel therapeutic strategies targeting these molecular factors to combat malaria more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in malaria-endemic regions who may be affected by Plasmodium falciparum infections.
Not a fit: Patients who do not reside in malaria-endemic areas or those who are not infected with malaria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for malaria, potentially reducing the disease's impact on affected populations.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation in malaria parasites, indicating that this approach could yield significant insights.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Le Roch, Karine Gaelle — University of California Riverside
- Study coordinator: Le Roch, Karine Gaelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.