Understanding how non-coding RNA affects stem cell behavior
Official title: Non-coding RNA in stem cell biology
Funded at Yale University · NIH-11089894 · Data updated 2026-11-12
This study is looking at how certain tiny molecules in stem cells help keep them healthy and stable, which could help us understand how to use stem cells better for healing and regeneration in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | May 21, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $504,175 |
| NIH project number | 1R35GM158281-01 |
| Project ID | NIH-11089894 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may be affected by conditions related to stem cell biology.
✕Less likely to help
Patients with conditions unrelated to stem cell biology or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of non-coding RNA in regulating gene expression and maintaining genomic stability in pluripotent stem cells. By studying a specific type of stem cell found in planarians, the researchers aim to uncover how these cells are preserved over time and how they transition into differentiated cells. The approach involves examining the function of PIWI-interacting RNAs (piRNAs) and their interactions with PIWI proteins, which are crucial for stem cell function and development. This research could provide insights into the mechanisms that govern stem cell behavior, potentially leading to advancements in regenerative medicine.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for conditions related to stem cell dysfunction, such as certain cancers and congenital abnormalities.
How similar studies have gone: Previous research has shown promising results in understanding the role of non-coding RNAs in stem cell biology, indicating that this approach has potential for success.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Van Wolfswinkel, Josephina C — Yale University
- Study coordinator: Van Wolfswinkel, Josephina C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.