Understanding how non-coding RNA affects immune cells in tumors
Non-coding RNA regulation of Myeloid Cells
This study is looking at how certain molecules in our cells can influence immune cells that help fight tumors, with the hope of finding new ways to make cancer treatments work better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10991136 on NIH RePORTER |
What this research studies
This research investigates the role of non-coding RNA in regulating tumor-associated immune macrophages (TAMs), which are crucial for both fighting tumors and promoting their growth. By examining how these immune cells differentiate within the tumor microenvironment, the study aims to uncover mechanisms that could lead to new cancer therapies. The research utilizes advanced techniques like single-cell transcriptomics and genetically modified mouse models to explore the effects of specific signals on TAM function. Patients may benefit from insights that could improve the effectiveness of cancer immunotherapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with tumors that are influenced by immune cell interactions, particularly those undergoing or considering immunotherapy.
Not a fit: Patients with non-cancerous conditions or those whose tumors are not influenced by immune cell dynamics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance anti-tumor immunity and improve cancer treatment outcomes.
How similar studies have performed: Previous research has shown promising results in understanding immune cell regulation in tumors, suggesting that this approach could yield significant insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Henao-Mejia, Jorge — University of Pennsylvania
- Study coordinator: Henao-Mejia, Jorge
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.