Understanding how non-coding RNA affects early brain cell development
Non-coding RNA regulation of early neural development
['FUNDING_R01'] · UNIVERSITY OF COLORADO · NIH-10748362
This study is looking at how certain molecules in our cells help brain cells grow and develop properly, which is important for preventing conditions like microcephaly, and it's using mice to learn more about these processes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO (nih funded) |
| Locations | 1 site (Boulder, UNITED STATES) |
| Trial ID | NIH-10748362 on ClinicalTrials.gov |
What this research studies
This research investigates the role of long non-coding RNA in the self-renewal and differentiation of neuroepithelial progenitor cells, which are crucial for brain development. By using mouse models and advanced techniques like CRISPR, the study aims to uncover how defects in these processes can lead to severe neurodevelopmental disorders, such as microcephaly. The research will explore the interactions between the non-coding RNA and proteins associated with microcephaly, providing insights into the cellular mechanisms involved in brain cell behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders, particularly those with conditions like microcephaly.
Not a fit: Patients with neurodevelopmental disorders unrelated to neuroepithelial progenitor cell dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating neurodevelopmental disorders.
How similar studies have performed: While the specific approach of targeting long non-coding RNA in this context is novel, similar studies have shown promise in understanding neurodevelopmental disorders.
Where this research is happening
Boulder, UNITED STATES
- UNIVERSITY OF COLORADO — Boulder, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NISWANDER, LEE A. — UNIVERSITY OF COLORADO
- Study coordinator: NISWANDER, LEE A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: neurodevelopmental disease, Neuronal Injury, neuron injury