Understanding how non-coding parts of our DNA regulate gene activity
Multi-omics functional analysis of non-coding regulatory genome for genomic medicine
This study is looking at how certain parts of our DNA and RNA that don’t code for proteins help control how our genes work, which is important for understanding health and diseases, and it’s for anyone interested in how our genes affect our bodies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10867351 on NIH RePORTER |
What this research studies
This research investigates the role of non-coding DNA and RNA sequences in regulating gene expression, which is crucial for understanding various biological processes and diseases. By employing innovative multi-omics approaches, the study aims to analyze the molecular components associated with these non-coding sequences. The goal is to uncover how these sequences interact with proteins to control gene activity, providing insights into their functions during different developmental stages. This could lead to a better understanding of the genetic factors involved in diseases and disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or diseases that may be influenced by non-coding genomic elements.
Not a fit: Patients with conditions unrelated to genetic regulation or those not affected by non-coding genomic elements may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic regulation, potentially leading to new therapeutic strategies for various diseases.
How similar studies have performed: Other research has shown promising results in understanding the role of non-coding DNA in gene regulation, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Diao, Yarui — Duke University
- Study coordinator: Diao, Yarui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.