Understanding how noise affects hearing and the brain
Auditory nerve synaptopathy and the central mechanisms underlying noise-induced hearing loss
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-11116985
This project aims to uncover how loud noises damage hearing and affect the brain, especially in younger individuals.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11116985 on ClinicalTrials.gov |
What this research studies
Noise-induced hearing loss is a common problem that can worsen with age, particularly if noise exposure happens early in life. This work explores how noise damages the connections between the ear and the brain, specifically focusing on changes in the cochlear nucleus, a key part of the central auditory system. By understanding these early changes, we hope to find ways to prevent or lessen permanent hearing damage. The goal is to identify how noise-related damage in the ear leads to changes in the brain that affect how we hear.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit anyone affected by or at risk for noise-induced hearing loss.
Not a fit: Patients seeking immediate clinical treatment for existing hearing loss may not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat noise-induced hearing loss and its effects on the brain.
How similar studies have performed: Previous studies have shown that noise can damage specific connections in the ear, but how these changes affect the central brain mechanisms of hearing is still being explored.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XIE, RUILI — OHIO STATE UNIVERSITY
- Study coordinator: XIE, RUILI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.