Understanding how NMD affects brain development in neural progenitor cells
The Role of NMD in Cortical Neural Progenitor Cells
This study is looking at how certain genetic changes affect the way brain cells develop, especially in kids with conditions like microcephaly, by using mice to see how these changes impact brain growth and function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-11055563 on NIH RePORTER |
What this research studies
This research investigates the role of nonsense-mediated mRNA decay (NMD) in the development of brain cells, particularly focusing on neural progenitor cells. By studying genetic mutations that impact NMD, the researchers aim to uncover how these changes can lead to neurodevelopmental disorders such as microcephaly. The approach involves manipulating specific genes in mouse models to observe the effects on cell behavior and brain development. Through advanced techniques in molecular biology and genetics, the study seeks to clarify the mechanisms by which NMD regulates the growth and function of brain cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders or those at risk due to genetic mutations affecting NMD.
Not a fit: Patients with neurodevelopmental disorders not linked to NMD mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into neurodevelopmental disorders and potential therapeutic strategies for affected patients.
How similar studies have performed: Previous research has shown that understanding genetic factors in neurodevelopment can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Zheng, Sika — University of California Riverside
- Study coordinator: Zheng, Sika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.