Understanding how NMD affects brain development and neurogenesis
The Role of NMD in Cortical Neural Progenitor Cells
This study is looking at how certain genetic changes that affect a process called nonsense-mediated mRNA decay (NMD) might impact brain development, especially in cells that help form the brain, to better understand how these changes could lead to neurodevelopmental disorders like microcephaly.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-10994132 on NIH RePORTER |
What this research studies
This research investigates the role of nonsense-mediated mRNA decay (NMD) in the development of the brain, particularly focusing on neural progenitor cells. By studying genetic mutations that affect NMD, the researchers aim to uncover how these mutations contribute to neurodevelopmental disorders. The approach involves manipulating specific genes in mouse models to observe changes in brain development and cell behavior. Through advanced techniques in molecular biology and genetics, the team will analyze how disruptions in NMD can lead to conditions like microcephaly.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders or those at risk due to genetic mutations affecting NMD.
Not a fit: Patients with neurodevelopmental disorders not linked to NMD mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of neurodevelopmental disorders and potential therapeutic strategies.
How similar studies have performed: Previous research has shown that understanding genetic factors in neurodevelopment can lead to significant advancements in treatment, indicating a promising avenue for this investigation.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Zheng, Sika — University of California Riverside
- Study coordinator: Zheng, Sika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.