Understanding how NLRP3 affects treatment resistance in melanoma
To Elucidate the Biological Function and Translational Potential of NLRP3 in Immunotherapy-resistant Melanoma
['FUNDING_OTHER'] · VA EASTERN COLORADO HEALTH CARE SYSTEM · NIH-11063219
This study is looking at how a specific part of the immune system affects melanoma in patients, especially veterans who struggle with current treatments, to find new ways to help them respond better to therapy.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VA EASTERN COLORADO HEALTH CARE SYSTEM (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11063219 on ClinicalTrials.gov |
What this research studies
This research investigates the role of NLRP3 in melanoma, particularly in patients who do not respond well to current immunotherapy treatments. By focusing on the inflammatory processes that contribute to melanoma progression, the study aims to uncover new therapeutic strategies that could improve outcomes for patients, especially veterans who are disproportionately affected by this disease. The research will involve analyzing tumor samples and patient data to identify how inflammation influences treatment resistance and exploring potential interventions targeting these pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research include veterans and other individuals with advanced melanoma who have not responded to standard immunotherapy treatments.
Not a fit: Patients with early-stage melanoma or those who have responded well to existing immunotherapy treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for melanoma patients who currently have limited responses to existing therapies.
How similar studies have performed: While the approach of targeting inflammatory pathways in melanoma is gaining interest, this specific investigation into NLRP3 is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
Aurora, UNITED STATES
- VA EASTERN COLORADO HEALTH CARE SYSTEM — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARCHETTI, CARLO — VA EASTERN COLORADO HEALTH CARE SYSTEM
- Study coordinator: MARCHETTI, CARLO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.