Understanding how NK cells respond to antibodies in cancer treatment
Modeling Antibody-induced Immune Responses by NK cells in Mice and Humans (Resubmission 1)
This study is looking at how certain immune cells called Natural Killer (NK) cells work with antibody treatments for cancer, and it aims to create models that help predict how these cells can be used to make cancer therapies even better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-11012284 on NIH RePORTER |
What this research studies
This research investigates the role of Natural Killer (NK) cells in the immune response to antibodies, particularly in the context of cancer therapy. It aims to develop computational models that predict how different NK cell types, including memory-like NK cells, respond to antibody-coated cells. By combining advanced data analysis techniques with laboratory experiments using human NK cells, the research seeks to enhance the effectiveness of monoclonal antibody therapies. Patients may benefit from improved cancer treatments that leverage the body's immune system more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who may benefit from antibody-based therapies.
Not a fit: Patients who do not have cancer or are not receiving antibody-based treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer immunotherapies that utilize the body's own immune responses.
How similar studies have performed: Previous research has shown promise in enhancing NK cell responses in similar contexts, suggesting potential for success in this approach.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Das, Jayajit — Research Inst Nationwide Children's Hosp
- Study coordinator: Das, Jayajit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.