Understanding how NK cells fight viral infections
Transcriptional control of NK cell metabolism
This study is looking at how special immune cells called natural killer (NK) cells fight off viral infections, like cytomegalovirus, and how their energy use affects their ability to do this, with the goal of finding ways to boost immune responses in people who need it most, like newborns and those with weakened immune systems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11012354 on NIH RePORTER |
What this research studies
This research investigates the role of natural killer (NK) cells in the immune response against viral infections, particularly focusing on how their metabolism is regulated during such responses. By using advanced techniques like metabolomics and engineered mouse models, the study aims to uncover the cellular and molecular mechanisms that enable NK cells to effectively combat viruses like cytomegalovirus. The findings could lead to new insights into enhancing immune responses in vulnerable populations, such as newborns and immunocompromised patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns and immunocompromised individuals who are particularly susceptible to viral infections.
Not a fit: Patients with robust immune systems and no history of viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve strategies for boosting immune responses in patients at high risk for viral infections.
How similar studies have performed: Previous research has shown promising results in understanding NK cell responses, but this specific approach focusing on metabolic regulation is relatively novel.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Sun, Joseph Chai-Yuen — Sloan-Kettering Inst Can Research
- Study coordinator: Sun, Joseph Chai-Yuen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.