Understanding how nitrogen mustard affects the eyes over time
Official title: Immune Mechanisms of Chronic Ocular Damage after Acute Exposure to Nitrogen Mustard
Funded at Schepens Eye Research Institute · NIH-10931164 · Data updated 2026-11-12
This study is looking at how exposure to nitrogen mustard affects the eyes over time, especially for people who might have eye problems from mustard gas, and it aims to find ways to help improve their vision by understanding how the immune system reacts.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Schepens Eye Research Institute NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 30, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $589,071 |
| NIH project number | 1R01EY035215-01A1 |
| Project ID | NIH-10931164 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced exposure to nitrogen mustard and are suffering from chronic ocular conditions.
✕Less likely to help
Patients who have not been exposed to nitrogen mustard or do not have related ocular conditions may not benefit from this research.
What this research studies
This research investigates the long-term effects of nitrogen mustard exposure on the eyes, particularly focusing on a condition called mustard gas keratopathy (MGK). Patients who have been exposed to nitrogen mustard may develop chronic eye issues that impair vision. The study uses a mouse model to explore the immune responses involved in MGK, particularly the role of specific immune cells that may contribute to ongoing damage. By understanding these mechanisms, the research aims to identify potential therapeutic targets for better management of eye health in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from chronic eye damage due to nitrogen mustard exposure.
How similar studies have gone: While the specific mechanisms of MGK are not well-studied, similar immune response investigations in other mustard exposure-related conditions have shown promising results.
Where this research is happening
-
Schepens Eye Research Institute
Boston, United States Active
Researchers
- Principal investigator: Chen, Yihe — Schepens Eye Research Institute
- Study coordinator: Chen, Yihe
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.