Understanding how nitro-fatty acids affect heart and blood vessel health
Nitro-Fatty Acids and Cardiovascular Disease
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11110430
This project explores how certain fats might protect blood vessels from damage in people with diabetes, aiming to prevent heart disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11110430 on ClinicalTrials.gov |
What this research studies
Heart disease is a major concern for people with diabetes because high blood sugar can harm blood vessels, leading to a condition called atherosclerosis. Our team is looking into a specific protein, TFEB, which appears to protect blood vessel cells from stress and inflammation. We believe that by understanding how TFEB works, especially with certain fats called nitro-fatty acids, we can find new ways to keep blood vessels healthy. This work uses advanced laboratory techniques to uncover how these processes interact at a cellular level.
Who could benefit from this research
Good fit: This research is relevant for individuals with diabetes who are at risk for or already have cardiovascular disease, particularly atherosclerosis.
Not a fit: Patients without diabetes or cardiovascular disease would not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that protect the heart and blood vessels in individuals with diabetes, reducing their risk of serious cardiovascular problems.
How similar studies have performed: Our previous work has shown that TFEB has beneficial effects in models of cardiovascular disease, suggesting this approach builds on promising preliminary findings.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, YUQING EUGENE — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: CHEN, YUQING EUGENE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.