Understanding how nitric oxide affects a key enzyme related to asthma and other diseases
Official title: Nitric oxide induced soluble guanylate cyclase dysfunction or activation: Implications as a disease indicator or in therapy
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-10845936 · Data updated 2026-11-12
This study is looking at how too much nitric oxide can mess with an important enzyme called sGC, which plays a key role in conditions like asthma, and it hopes to find new ways to help improve treatments for asthma and similar issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 15, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $77,280 |
| NIH project number | 3R01HL150049-04S1 |
| Project ID | NIH-10845936 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with asthma or other inflammatory conditions that may involve nitric oxide and sGC dysfunction.
✕Less likely to help
Patients without asthma or related inflammatory conditions may not receive any benefit from this research.
What this research studies
This research investigates the role of nitric oxide in the dysfunction of soluble guanylate cyclase (sGC), an important enzyme involved in various biological processes. The study focuses on how elevated levels of nitric oxide can lead to sGC dysfunction, particularly in inflammatory conditions like asthma. By examining the interactions between sGC and other proteins, the research aims to identify potential biomarkers for disease and explore therapeutic options that could restore sGC function. Patients may benefit from insights that could lead to new treatments for asthma and related disorders.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools and therapies for asthma and other conditions associated with sGC dysfunction.
How similar studies have gone: Previous studies have shown that targeting sGC can improve outcomes in conditions like asthma, indicating that this approach has potential for success.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Ghosh, Arnab — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Ghosh, Arnab
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.