Understanding how nitric oxide affects a key enzyme related to asthma and other diseases
Nitric oxide induced soluble guanylate cyclase dysfunction or activation: Implications as a disease indicator or in therapy
This study is looking at how high levels of nitric oxide can affect an important enzyme that helps with breathing in asthma patients, and it hopes to find new ways to improve treatments by understanding these effects better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10657664 on NIH RePORTER |
What this research studies
This research investigates the role of nitric oxide in the dysfunction of soluble guanylate cyclase (sGC), an important enzyme involved in various biological processes, particularly in asthma. The study aims to understand how elevated levels of nitric oxide can disrupt the normal function of sGC, leading to difficulties in bronchodilation, which is crucial for asthma patients. By exploring the interactions between sGC and other proteins, the research seeks to identify potential biomarkers for disease and therapeutic targets that could improve treatment outcomes. The approach includes examining the molecular mechanisms at play and testing sGC activators that may restore function despite the presence of nitric oxide.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with asthma, particularly those experiencing difficulties with bronchodilation.
Not a fit: Patients without asthma or those whose condition does not involve sGC dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and therapies for asthma and related conditions by targeting sGC dysfunction.
How similar studies have performed: Previous studies have shown promising results in understanding the role of nitric oxide in sGC dysfunction, indicating that this research builds on established findings.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Ghosh, Arnab — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Ghosh, Arnab
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.