Understanding how nicotine affects brain inflammation in people with HIV
Investigating the role of nicotine and the NRLP3 Inflammasome in HIV-1-Associated CNS Inflammation
This study is looking at how smoking nicotine might affect brain inflammation in people with HIV, aiming to understand how this interaction could impact thinking and memory, so we can find better ways to help those who smoke and live with HIV.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11085355 on NIH RePORTER |
What this research studies
This research investigates the impact of nicotine on neuroinflammation in individuals living with HIV. It focuses on how nicotine and HIV-1 interact to activate the NLRP3 inflammasome, which plays a crucial role in inflammation and cognitive impairment. By using advanced models, including humanized mice, the study aims to uncover the mechanisms behind this interaction and its effects on the blood-brain barrier. The findings could lead to better understanding and management of cognitive issues in HIV patients who smoke.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who also use nicotine products.
Not a fit: Patients who do not have HIV or do not use nicotine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cognitive impairment in HIV patients, particularly those who use tobacco.
How similar studies have performed: Previous research has shown that targeting the NLRP3 inflammasome can be effective in managing inflammation, suggesting potential for success in this novel approach.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Keane, Aislinn — Icahn School of Medicine at Mount Sinai
- Study coordinator: Keane, Aislinn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.