Understanding how nicotine addiction affects the brain
Neuroinflammatory and glutamatergic mechanisms of nicotine seeking
['FUNDING_R01'] · UNIVERSITY OF KENTUCKY · NIH-10899797
This study is looking at how nicotine affects the brain and what might help people who are trying to quit smoking, specifically testing a supplement called N-acetylcysteine (NAC) to see if it can reduce cravings and help prevent relapse.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KENTUCKY (nih funded) |
| Locations | 1 site (LEXINGTON, UNITED STATES) |
| Trial ID | NIH-10899797 on ClinicalTrials.gov |
What this research studies
This research investigates the neurobiological mechanisms behind nicotine addiction and relapse, focusing on how nicotine alters brain function, particularly in areas related to reward. The study examines the role of glutamate receptors and the impact of N-acetylcysteine (NAC), an antioxidant, in reducing nicotine-seeking behavior. By exploring how exposure to nicotine-related cues influences relapse, the research aims to identify potential therapeutic strategies to help individuals overcome addiction. Patients may be involved in trials assessing the effectiveness of NAC in managing cravings and withdrawal symptoms.
Who could benefit from this research
Good fit: Ideal candidates for participation would be individuals struggling with nicotine addiction or those who have a history of smoking and are seeking help to quit.
Not a fit: Patients who do not use nicotine products or have never been addicted to nicotine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help individuals reduce their nicotine cravings and prevent relapse.
How similar studies have performed: Previous research has shown promising results with NAC in reducing cravings and withdrawal symptoms in other forms of addiction, suggesting potential success for this approach.
Where this research is happening
LEXINGTON, UNITED STATES
- UNIVERSITY OF KENTUCKY — LEXINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GIPSON-REICHARDT, CASSANDRA D — UNIVERSITY OF KENTUCKY
- Study coordinator: GIPSON-REICHARDT, CASSANDRA D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.