Understanding how NGN3 affects pancreatic cell development
Official title: Investigating the role of NGN3 in Notch signaling repression during pancreatic endocrinogenesis
Funded at Children's Hospital of Los Angeles · NIH-11164406 · Data updated 2026-11-12
This study is looking at how a protein called NGN3 helps develop the insulin-producing cells in the pancreas, which is important for people with diabetes, by using special stem cells to learn more about how these cells grow and work together.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $46,649 |
| NIH project number | 1F31DK143749-01 |
| Project ID | NIH-11164406 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with type 2 diabetes who may benefit from advanced cellular therapies targeting pancreatic beta cell dysfunction.
✕Less likely to help
Patients who do not have type 2 diabetes or those whose diabetes is not related to pancreatic beta cell dysfunction may not benefit from this research.
What this research studies
This research investigates the role of the NGN3 protein in the development of pancreatic beta cells, which are crucial for insulin production. By analyzing patient-specific stem cells, the research aims to uncover how NGN3 influences the maturation of these cells and their interactions with other cell types in the pancreas. The study employs advanced techniques like single-cell transcriptome and chromatin analyses to explore the genetic and epigenetic factors involved in pancreatic development. This could lead to improved methods for generating functional beta cells for diabetes treatment.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of stem cell therapies for patients with type 2 diabetes by producing more mature and functional insulin-producing cells.
How similar studies have gone: Previous research has shown promising results in understanding pancreatic cell development, but the specific role of NGN3 in this context is still being explored, making this a novel investigation.
Where this research is happening
-
Children's Hospital of Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Wang, Victoria Liwen — Children's Hospital of Los Angeles
- Study coordinator: Wang, Victoria Liwen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.