Understanding how NF-kappaB works in lung health and cancer
Mechanistic difference of NF-kappaB in lung physiology and tumorigenesis
This study is looking at how a protein called NF-kappaB works in healthy lungs and in lung cancer, to find new ways to treat lung cancer without harming normal lung function, and it could help improve treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10894751 on NIH RePORTER |
What this research studies
This research investigates the dual roles of the NF-kappaB protein in lung physiology and cancer development. By differentiating between its normal and cancer-related functions, the study aims to identify new therapeutic targets that could selectively inhibit cancer growth without affecting healthy lung function. The researchers will explore how a specific protein, PDLIM2, influences NF-kappaB activity in lung cells, potentially leading to innovative treatment strategies for lung cancer. Patients may benefit from insights that could improve cancer therapies and reduce resistance to treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with lung cancer who are seeking new treatment options.
Not a fit: Patients with non-cancerous lung conditions or those not diagnosed with lung cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that specifically target tumor growth while preserving normal lung function.
How similar studies have performed: Previous research has shown promise in targeting NF-kappaB pathways in cancer, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Qu, Zhaoxia — University of Southern California
- Study coordinator: Qu, Zhaoxia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.