Understanding how newborn metabolic profiles and genetics contribute to childhood asthma
Official title: Identifying molecular pathways in childhood asthma pathogenesis by integrating newborn metabolic profiles and GWAS data
Funded at Vanderbilt University Medical Center · NIH-10875665 · Data updated 2026-11-12
This study is looking at how certain changes in newborns' metabolism and genes might help us predict if they will develop asthma as they grow up, so we can better understand what causes this condition in kids.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $130,607 |
| NIH project number | 5K01HL161257-03 |
| Project ID | NIH-10875665 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns and infants up to 4 weeks old, particularly those with a family history of asthma or related conditions.
✕Less likely to help
Patients who are older than 11 years or those without a family history of asthma may not benefit from this research.
What this research studies
This research investigates the molecular pathways that lead to childhood asthma by examining metabolic profiles from newborns and genetic data. The study aims to identify specific metabolic markers at birth that may predict the development of asthma later in childhood. By analyzing a large cohort of children, researchers will explore how genetic variations influence these metabolic profiles and their relationship to asthma. This approach combines both genetic and environmental factors to enhance our understanding of asthma's origins.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies for childhood asthma by identifying at-risk infants early.
How similar studies have gone: Previous research has shown promise in identifying genetic and metabolic factors related to asthma, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Snyder, Brittney M — Vanderbilt University Medical Center
- Study coordinator: Snyder, Brittney M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.