Understanding how newborn hearts can heal after injury
Transcriptional Control of Neonatal Heart Regeneration
This study is looking at how baby hearts can heal themselves better than adult hearts after an injury, and it aims to find ways to help adult hearts recover too, using special techniques to understand the healing process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10980543 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the heart's ability to regenerate, particularly focusing on the differences between neonatal and adult hearts. By analyzing gene expression and epigenetic changes in neonatal mouse hearts, the researchers aim to uncover the factors that enable regeneration after severe injury. The study employs advanced techniques like single-cell RNA sequencing to explore the cellular responses involved in heart repair. Ultimately, the goal is to apply this knowledge to develop new treatments that could help adult hearts recover from damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart conditions or injuries, particularly those who are adults and may benefit from enhanced cardiac repair strategies.
Not a fit: Patients with non-cardiac conditions or those whose heart issues are not related to regenerative capacity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance heart regeneration in adults, potentially improving outcomes for patients with heart disease.
How similar studies have performed: Previous research has shown promising results in understanding cardiac regeneration in neonatal models, suggesting that this approach could yield significant advancements in adult heart repair.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Olson, Eric N — Ut Southwestern Medical Center
- Study coordinator: Olson, Eric N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.