Understanding how newborn hearts adapt to life outside the womb
Epigenetic regulation of the metabolic shift in mammalian perinatal hearts
This study looks at how baby hearts change when they are born and start living outside the womb, using mice to learn more about the proteins that help these changes happen, which could eventually help us find better treatments for heart problems in newborns.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-11072071 on NIH RePORTER |
What this research studies
This research investigates the critical metabolic changes that occur in mammalian hearts during the transition from the womb to the outside environment. By using mouse models, the study aims to uncover the molecular mechanisms that regulate these changes, particularly focusing on the role of specific proteins that influence heart development. The findings could lead to new insights into treating heart conditions that affect newborns, particularly those related to metabolic shifts. The research employs advanced genetic techniques to manipulate and observe heart function in these models.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include newborns diagnosed with congenital heart defects or related cardiac conditions.
Not a fit: Patients with fully developed hearts and no history of cardiac issues are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for congenital heart defects and other cardiomyopathies in newborns.
How similar studies have performed: Previous research has shown promising results in understanding cardiac development and metabolic shifts, suggesting that this approach could yield valuable insights.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Jiao, Kai — Augusta University
- Study coordinator: Jiao, Kai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.