Understanding how new tuberculosis infections spread in Kampala, Uganda
Capturing spatial patterns of new M. tuberculosis infection in Kampala, Uganda
This study is looking at how new tuberculosis infections spread in Kampala, Uganda, and aims to find out who is most at risk of getting sick so they can get help sooner, using blood samples to spot signs of recent infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10923497 on NIH RePORTER |
What this research studies
This research investigates the patterns of new Mycobacterium tuberculosis infections in Kampala, Uganda, focusing on identifying individuals at high risk for developing active tuberculosis. By analyzing serum samples from household contacts of TB patients, the study aims to discover specific protein signatures that indicate recent infections. This information will help target preventive therapy to those most likely to progress to disease, thereby reducing transmission rates in the community. The approach combines epidemiological data with advanced proteomic analysis to enhance TB control efforts.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living in high TB transmission areas, particularly those who have been in close contact with TB patients.
Not a fit: Patients who are not in high-risk areas or who have not been exposed to TB may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of tuberculosis by enabling targeted preventive treatment for those at highest risk.
How similar studies have performed: Previous research has shown promise in using biomarker signatures to identify recent TB infections, indicating that this approach could be effective.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Bark, Charles Martyn — Case Western Reserve University
- Study coordinator: Bark, Charles Martyn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.