Understanding how new neurons connect in the developing brain
Official title: A Connectomic Analysis of a Developing Brain Undergoing Neurogenesis
Funded at University of Massachusetts Amherst · NIH-11256300 · Data updated 2026-11-12
This study is looking at how new brain cells connect with each other as the brain develops, using a special type of sea slug, and it hopes to help us understand brain development better, which could lead to new treatments for brain-related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Massachusetts Amherst NIH-funded |
| Lab location | 1 site (Hadley, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $23,552 |
| NIH project number | 3R01NS133654-02S1 |
| Project ID | NIH-11256300 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with neurological conditions or those interested in brain development, particularly in the context of neurogenesis.
✕Less likely to help
Patients with fully developed brains or those not affected by neurological conditions may not receive direct benefits from this research.
What this research studies
This research investigates the formation of neural circuits in the developing brain by examining how new neurons integrate into existing networks. Using a unique animal model, the mollusc Berghia stephanieae, researchers will create detailed wiring diagrams of the brain at various stages of development. By tracking changes in specific neurons and their connections, the study aims to uncover the mechanisms behind neural circuit formation and how these processes may relate to neurological conditions. Patients may benefit from insights gained into brain development and potential therapeutic targets for related disorders.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of brain development and new strategies for treating neurological conditions.
How similar studies have gone: Other research has shown success in understanding neural circuit formation using similar approaches, but this specific model and methodology may offer novel insights.
Where this research is happening
-
University of Massachusetts Amherst
Hadley, United States Active
Researchers
- Principal investigator: Katz, Paul S — University of Massachusetts Amherst
- Study coordinator: Katz, Paul S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.