Understanding how new lipids affect insulin resistance and diabetes
Mechanisms for the regulation of novel lipids in vivo
['FUNDING_CAREER'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-11081778
This study is looking at a new type of fat in the body called PAHSAs to see how it affects insulin sensitivity and resistance in people with type 2 diabetes, with the hope that understanding this could help create better treatments for managing the condition.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11081778 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a newly discovered class of lipids, known as Palmitic Acid Hydroxy Stearic Acids (PAHSAs), in regulating insulin sensitivity and resistance, particularly in the context of type 2 diabetes. The study aims to uncover the molecular mechanisms that control PAHSA levels in the body and identify the enzymes involved in their production and breakdown. By using genetic mouse models that mimic human metabolic variations, the research seeks to provide insights into how these lipids can be manipulated to improve insulin sensitivity and potentially prevent or treat diabetes. Patients may benefit from the findings as they could lead to the development of new therapeutic strategies for managing diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of or currently living with type 2 diabetes, particularly those experiencing insulin resistance.
Not a fit: Patients with type 1 diabetes or those whose diabetes is not related to insulin resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve insulin sensitivity and help manage or prevent type 2 diabetes.
How similar studies have performed: Other research has shown promise in targeting lipid metabolism for improving insulin sensitivity, suggesting that this approach could yield significant advancements.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SANTORO, ANNA — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: SANTORO, ANNA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus