Understanding how new life begins in early development
Molecular mechanisms of the maternal to zygotic transition
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-11164803
This work explores how an embryo first begins to use its own genetic instructions right after conception.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11164803 on ClinicalTrials.gov |
What this research studies
This project looks closely at the earliest moments of life, specifically how an embryo switches from using its mother's genetic messages to activating its own genes. Researchers want to understand the 'code' that tells these genes when to turn on and off, and how proteins help manage this process. They are using advanced techniques like genetic assays, protein mapping, and special imaging to see these changes happening. The goal is to uncover the fundamental rules that guide the very first stages of development in vertebrates. This foundational knowledge could help us understand many biological processes.
Who could benefit from this research
Good fit: This foundational biological work does not involve direct patient participation.
Not a fit: Patients seeking immediate treatment options will not directly benefit from this basic science investigation.
Why it matters
Potential benefit: Understanding these fundamental processes could provide insights into early developmental problems, infertility, and how cells are reprogrammed, which might have implications for understanding diseases like cancer.
How similar studies have performed: While some individual factors in early development have been identified, this project aims to uncover the broader, integrated mechanisms, representing a novel approach to understanding this complex transition.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GIRALDEZ, ANTONIO J — YALE UNIVERSITY
- Study coordinator: GIRALDEZ, ANTONIO J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers