Understanding how new genetic mutations occur in primates
Dissecting the mechanisms and timing of de novo mutations in primates
['FUNDING_R01'] · TRUSTEES OF INDIANA UNIVERSITY · NIH-11031403
This study is looking at how and when new genetic changes happen in baby monkeys, specifically rhesus macaques, to help us better understand the origins of genetic disorders that can affect people.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TRUSTEES OF INDIANA UNIVERSITY (nih funded) |
| Locations | 1 site (BLOOMINGTON, UNITED STATES) |
| Trial ID | NIH-11031403 on ClinicalTrials.gov |
What this research studies
This research investigates the timing and mechanisms behind new genetic mutations that arise during the development of primates, particularly focusing on the rhesus macaque. By analyzing genetic material from multiple offspring within families, the study aims to identify when and how these mutations occur during embryonic and gametic development. The researchers will use advanced sequencing techniques to detect mutations in both parents and their offspring, providing insights into the mutation rates and patterns. This work could enhance our understanding of genetic disorders and their origins.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of genetic disorders or those interested in understanding the genetic risks associated with their lineage.
Not a fit: Patients who do not have a family history of genetic disorders or are not interested in genetic research may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic mutations that contribute to various diseases, potentially informing prevention and treatment strategies.
How similar studies have performed: Previous research has shown success in understanding genetic mutations through similar sequencing approaches, indicating that this methodology is promising.
Where this research is happening
BLOOMINGTON, UNITED STATES
- TRUSTEES OF INDIANA UNIVERSITY — BLOOMINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAHN, MATTHEW WILLIAM — TRUSTEES OF INDIANA UNIVERSITY
- Study coordinator: HAHN, MATTHEW WILLIAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: communicable disease transmission