Understanding how new genetic mutations occur in primates
Official title: Dissecting the mechanisms and timing of de novo mutations in primates
Funded at Trustees of Indiana University · NIH-11031403 · Data updated 2026-11-12
This study is looking at how and when new genetic changes happen in baby monkeys, specifically rhesus macaques, to help us better understand the origins of genetic disorders that can affect people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | May 15, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $399,318 |
| NIH project number | 5R01HD107120-03 |
| Project ID | NIH-11031403 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of genetic disorders or those interested in understanding the genetic risks associated with their lineage.
✕Less likely to help
Patients who do not have a family history of genetic disorders or are not interested in genetic research may not receive direct benefits from this research.
What this research studies
This research investigates the timing and mechanisms behind new genetic mutations that arise during the development of primates, particularly focusing on the rhesus macaque. By analyzing genetic material from multiple offspring within families, the study aims to identify when and how these mutations occur during embryonic and gametic development. The researchers will use advanced sequencing techniques to detect mutations in both parents and their offspring, providing insights into the mutation rates and patterns. This work could enhance our understanding of genetic disorders and their origins.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic mutations that contribute to various diseases, potentially informing prevention and treatment strategies.
How similar studies have gone: Previous research has shown success in understanding genetic mutations through similar sequencing approaches, indicating that this methodology is promising.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Hahn, Matthew William — Trustees of Indiana University
- Study coordinator: Hahn, Matthew William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.