Understanding how new brain cells affect seizures and thinking during alcohol withdrawal
The role of hippocampal neurogenesis in alcohol withdrawal seizure and cognition
This study is looking at how stopping alcohol affects the brain, especially a part called the hippocampus that helps with memory and emotions, to see if new brain cells can help prevent seizures and thinking problems during withdrawal, and it could lead to better treatments for people going through this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10817897 on NIH RePORTER |
What this research studies
This research investigates the impact of alcohol withdrawal on the brain, specifically focusing on the hippocampus, which is crucial for memory and emotion. It aims to understand how the generation of new brain cells in this area may influence the development of seizures and cognitive impairments associated with alcohol withdrawal. By employing advanced genetic techniques, the study will map the neural circuits involved in these processes, potentially leading to new treatment strategies for individuals experiencing alcohol withdrawal. Patients may be monitored for changes in brain function and behavior as part of this investigation.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of alcohol use disorder who experience withdrawal symptoms.
Not a fit: Patients who do not have a history of alcohol use or those not experiencing withdrawal symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for managing seizures and cognitive issues in individuals undergoing alcohol withdrawal.
How similar studies have performed: Previous research has shown promising results in understanding the role of neurogenesis in various neurological conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Suh, Hoonkyo — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Suh, Hoonkyo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.