Understanding how new brain cells affect memory in Alzheimer's disease.
Hippocampal neurogenesis in cognitive function and dysfunction in Alzheimer's disease.
This study is looking at how new brain cells grow in a part of the brain important for memory, especially in people with Alzheimer's and similar conditions, to see how this growth relates to their thinking abilities and to find ways to help improve memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11094760 on NIH RePORTER |
What this research studies
This research investigates the formation of new neurons in the hippocampus, a brain region crucial for memory, particularly in individuals with Alzheimer's disease and related dementias. By examining brain samples from participants with varying cognitive abilities, the study aims to determine how neurogenesis correlates with cognitive function. The researchers will analyze the presence of new neurons and other brain cells to understand their roles in cognitive decline and potential therapeutic approaches. This work could lead to insights into how to enhance memory and cognitive function in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults aged 21 and older who are experiencing cognitive decline or have been diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with cognitive impairments unrelated to Alzheimer's disease or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive decline in Alzheimer's patients.
How similar studies have performed: Previous studies have shown varying results regarding neurogenesis in humans, indicating that this research could provide novel insights into the topic.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Lazarov, Orly — University of Illinois at Chicago
- Study coordinator: Lazarov, Orly
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.