Understanding how neutrophils respond to trauma and inflammation
Neutrophils in polytrauma – from recruitment to phenotypic and functional reprogramming
This study is looking at how a type of white blood cell called neutrophils responds to injuries and ongoing inflammation, to help understand why some people have serious complications after trauma, with the hope of finding better treatments for those affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10847416 on NIH RePORTER |
What this research studies
This research investigates the role of neutrophils, a type of white blood cell, in response to traumatic injuries and chronic inflammation. It aims to understand how these cells are recruited to injury sites and how their function changes in patients with ongoing low-grade inflammation. By studying the mechanisms that regulate neutrophil behavior, the research seeks to uncover why some patients experience severe complications after trauma, such as infections and organ failure. The findings could lead to improved treatment strategies for patients suffering from traumatic injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced traumatic injuries and have underlying chronic inflammation.
Not a fit: Patients with isolated injuries and no history of chronic inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management of trauma patients, reducing complications and improving recovery outcomes.
How similar studies have performed: Previous research has shown that understanding immune responses in trauma can lead to significant improvements in patient care, indicating that this approach has potential for success.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: De Oliveira, Sofia — Albert Einstein College of Medicine
- Study coordinator: De Oliveira, Sofia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.