Understanding how neutrophils respond to tissue damage and infection
Official title: Secondary Analysis of Existing Datasets to Define the Neutrophil Transcriptomic Response to Parenchymal Damage
Funded at University of Southern California · NIH-11163311 · Data updated 2026-11-12
This study looks at how certain immune cells called neutrophils change when the body experiences tissue damage or infections, using data from patients with serious conditions like septic shock or those recovering from major surgeries, to help us better understand how our bodies fight off these challenges.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $124,500 |
| NIH project number | 5R21HL175493-02 |
| Project ID | NIH-11163311 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients who have experienced septic shock due to infections or have undergone major surgeries that may lead to parenchymal damage.
✕Less likely to help
Patients with infections that do not involve tissue damage, such as those with primary bloodstream or urinary tract infections, may not benefit from this research.
What this research studies
This research investigates the gene expression changes in neutrophils, which are key immune cells, in response to various types of tissue damage and infections. By analyzing existing data from patients with conditions like septic shock and those recovering from major surgeries, the researchers aim to identify common patterns in neutrophil behavior. The study will utilize advanced techniques such as RNA sequencing to uncover the biological pathways involved in these immune responses. This could help in understanding how the body reacts to severe infections and injuries.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from severe infections and tissue damage.
How similar studies have gone: Previous research has shown that analyzing gene expression in immune cells can provide valuable insights into inflammatory responses, suggesting that this approach has potential for success.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Siletz, Anaar Eastoak — University of Southern California
- Study coordinator: Siletz, Anaar Eastoak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.